Avtor/Urednik		Kragelj, Borut; Zaletel-Kragelj, Lijana
Naslov		Urinary incontinence after high-dose-rate brachytherapy boost treatment for prostate cancer
Tip		članek
Vol. in št.		Letnik 15, št. 4
Leto izdaje		2016
Obseg		str. 442-449
ISSN		1538-4721 - Brachytherapy
Jezik		eng
Abstrakt		Purpose To evaluate urinary incontinence (UI) and to elucidate potential risk factors important for the appearance or deterioration of pre-existing UI after high-dose-rate boost treatment of prostate cancer. Methods and Materials The change in grade of UI regarding the state at the start of treatment was assessed in 88 patients, consecutively treated from October 2006 through April 2011 with high-dose-rate brachytherapy of 3 X 6-7 Gy to 50-50.4 Gy of external-beam radiation. Increase in UI grade was defined as deterioration of UI (DUI). The impact of patients and treatment characteristics on third year prevalence of DUI was analyzed by using binary logistic regression method. Results At third year, DUI of followup was evidenced in 17/81 (20.9%) patients. It significantly impacted micturition quality (p = 0.015) and was associated with View the MathML sourceD[sub]2ccbladdervolume (odds ratio [OR]: 1.14; 95% confidence interval [CI]: 1.03-1.26; p = 0.010), diabetes (OR: 6.73; 95% CI: 1.17-38.56; p = 0.032), and initial nocturnal micturition frequency (OR: 3.72; 95% CI: 1.03-13.04; p = 0.045). Based on a multivariate model, a range of safe View the MathML sourceD[sub]2ccbladdervolume(EQD2) doses is suggested (no risk factor: 21.9 Gy, frequent initial nocturnal micturition only: 12.0 Gy, diabetes only: 7.6 Gy, both risk factors: no safe dose). Conclusions The study featured on urinary bladder base as a risk structure for UI. By taking account of the dose to urinary bladder base in conjunction with diabetes and initial nocturnal micturition frequency, the risk of UI could be reduced.
Proste vsebinske oznake		urinska inkontinenca rak na prostati visoki odmerki brahiterapije urinary incontinence prostate cancer high-dose-rate brachytherapy