Avtor/Urednik		Čemažar, Maja; Ambrožič, Jerneja; Pavlin, Darja; Serša, Gregor; Poli, Alessandro; Krhač Levačić, Ana; Tešić, Nataša; Lampreht Tratar, Urša; Rak, Mitja; Tozon, Nataša
Naslov		Efficacy and safety of electrochemotherapy combined with peritumoral IL-12 gene electrotransfer of canine mast cell tumours
Tip		članek
Vol. in št.		Letnik 15, št. 2
Leto izdaje		2017
Obseg		str. 641-654
ISSN		1476-5829 - Veterinary and comparative oncology
Jezik		eng
Abstrakt		Electrochemotherapy combined with peritumoral interleukin-12 (IL-12) gene electrotransfer was used for treatment of mast cell tumours in 18 client-owned dogs. Local tumour control, recurrence rate, as well as safety of combined therapy were evaluated. One month after the therapy, no side effects were recorded and good local tumour control was observed with high complete responses rate which even increased during the observation period to 72%. IL-12 gene electrotransfer resulted in 78% of patients with detectable serum IFN-% and/or IL-12 levels. In the treated tumours vascular changes as well as minimal T-lymphocytes infiltration was observed. After 1 week, the plasmid DNA was not detected intra- or peritumorally and no horizontal gene transfer was observed. In summary, our study demonstrates high antitumour efficacy of electrochemotherapy combined with IL-12 electrotransfer, which also prevented recurrences or distant metastases, as well as its safety and feasibility in treatment of canine mast cell tumours.
Proste vsebinske oznake		dogs efficacy electrochemotherapy interleukin-12 psi učinkovitost elektrokemoterapija interlevkin-12