Avtor/Urednik		Gubina, M; Ihan, A; Ferlan-Marolt, V; Tepeš, B; Logar-Car, G; Križman, I
Naslov		Helicobater pylori ter naše diagnostične in terapevtske izkušnje
Prevedeni naslov		Helicobacter pylori and our diagnostical and therapeutical experiences
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 64, št. Suppl 3
Leto izdaje		1995
Obseg		str. III-47-9
Jezik		slo
Abstrakt		Background. Helicobacter (H.) pylori is the major etiological agent of active gastritis, peptic ulcer disease and is associated with gastric cancer. It is estimated that 50 percent of world population is infected. The majority of infected individuals are asymptomatic. Histology of culture of biopsies are necessary for detection of H. pylori infection. Successful eradication reduces of H. pylori, therefore the inflammatory characteristics gradually disappear. The active chronic gastritis cures during the first year period. At the same time chronic ulcer disease heals as well. In Slovenia, the pathohistological and microbiological diagnostics of H. pylori infections have been introduced during the last ten years. A positive rapid urease test help the endoscopiests to detect the H. pylori in biopsy specimens. After the 1990, some groups of patients have been treated by antimicrobials. The eradication of H. pylori has been demonstrated in 83-97 percent. Long term follow-up eradication confirms the successful treatment and calls for further research of immunological response to isolated strains and pathogenic factors of H. pylori. Conclusions: H. pylori has been recognised as the etiological agent of chronic gastritis, ulcer disease, gastric carcinoma and MALT lymphoma. In our country, the doctrinally recommended diagnostics and antimicrobial treatment were introduced at adult and children patients.
Izvleček		Izhodišča. Helicobacter (h.) pylori je glavni povzročitelj aktivnega gastritisa in ulkusne bolezni ter pomemben kokarcinogen v želodcu. Ocenjujejo, da je s to bakterijo okužena polovica svetovnega prebivalstva. Večina okuženih nima bolezenskih znakov. Okužbo s H. pylori dokazujemo s histološkim pregledom ali s kultiviranjem biopsijskih vzorcev. Z eradikacijskim zdravljenjem je mogoče H. pylori odstraniti, s čimer izginejo tudi bolezenski znaki. V Sloveniji smo v zadnjih desetih letih uvedli patohistološko in mikrobiološko diagnostiko. Pozitivni hitri ureazni test omogoča gastreoenterologu, da zanesljivo oceni navzočnost H. pylori v biopsijskem vzorcu. Po letu 1990 so dobile prve skupine bolnikov antimikrobna zdravila, pri čemer smo doseli 83-97 odst. eradikacijo. Dolgoročno spremljanje uspešnosti zdravljenja je potrdilo terapevtske dosežke, ker nas vodi v nadaljne raziskave o dejavnikih patogenosti in imunskem odgovoru na izolirane seve. Zaključek. H. pylori povzroča kronični gastritis, ulkusno bolezen, raka na želodcu in MALT limfom. Pri nas smo uvedli mednarodno doktrinarno priporočeno diagnostiko ter antimikrobno zdravljenje odraslih bolnikov in bolnih otrok.
Deskriptorji		HELICOBACTER INFECTIONS HELICOBACTER PYLORI