Avtor/Urednik		Merlini, Luciano; Bonaldo, Paolo; Marzetti, Emanuele
Naslov		Pathophysiological mechanisms of sarcopenia in aging and in muscular dystrophy
Tip		monografija
Kraj izdaje		Lausanne
Založnik		Frontiers
Leto izdaje		2017
Obseg		str. 248 str.
ISBN		978-2-88919-684-5
Jezik		eng
Abstrakt		Loss of muscle mass and increased fibrosis characterize both sarcopenia of aging and muscular dystrophy. Research is increasingly showing that these two conditions also share several pathophysiological mechanisms, including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autophagy, decline in satellite cells, increased generation of reactive oxygen species, and abnormal regulation of signaling and stress response pathways. This Research Topic will cover several mechanisms involved in aging and dystrophic sarcopenia and explore the therapeutic potential of various strategies for intervention
Proste vsebinske oznake		sarcopenia muscular dystrophy skeletal muscle frailty autophagy