Avtor/Urednik | Traxler, Denise; Lainščak, Mitja; Simader, Elisabeth; Ankersmit, Hendrik Jan; Jug, Borut | |
Naslov | Heat shock protein 27 acts as a predictor of prognosis in chronic heart failure patients | |
Tip | članek | |
Vol. in št. | , št. Vol. 473 | |
Leto izdaje | 2017 | |
Obseg | str. 127-132 | |
ISSN | 0009-8981 - Clinica chimica acta; international journal of clinical chemistry | |
Jezik | eng | |
Abstrakt | Heat shock proteins (HSPs) represent intracellular mechanisms of stress response. Clinical implications of their (systemic) expression in patients with chronic heart failure (HF) remain inconclusive. METHODS: In outpatients with chronic stable HF plasma HSP27 levels were measured using ELISA. Patients were followed for a minimum of one year, and a multivariate Cox proportional hazard model was built for cardiovascular death or HF-associated hospitalisations. RESULTS: A total of 134 patients with chronic HF (mean age 71%10years, 34% female, mean LVEF 36%12%) were included. During a mean follow-up of 527%260days, 44 patients (33%) experienced an event. Mean time to event was 350%236days. In a Kaplan-Meier survival analysis HSP27 levels above the median (3820pg/ml) indicate a higher risk for an event (p=0.03). Increased HSP27 levels remained an independent predictor of events (HR, 2.33 CI 95% 1.12-4.87, p=0.024) even after adjustment for age, gender, NT-proBNP, LVEF, aetiology, smoking status, kidney function and NYHA class. CONCLUSIONS: HSP27 is an independent predictor of prognosis in chronic HF. Our findings suggest that HSP27 may improve risk-stratification in chronic HF beyond known prognostic predictors. | |
Proste vsebinske oznake | kronično srčno popuščanje srčno popuščanje napovedi vnetni proteini chronic heart failure heart failure prognosis inflammatory proteins |