Avtor/Urednik		Ferjan, Simona; Janež, Andrej; Jensterle Sever, Mojca
Naslov		DPP4 inhibitor sitagliptin as a potential treatment option in metformin intolerant obese women with polycystic ovary syndrome
Tip		članek
Leto izdaje		2017
Obseg		str. str.
ISSN		1934-2403 - Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Jezik		eng
Abstrakt		Objective: Metformin has an established role in the management of polycystic ovary syndrome (PCOS). Some patients cannot tolerate it due to associated gastrointestinal adverse events. The present study evaluated DPP4 inhibitor sitagliptin as a potential treatment option in metformin intolerant PCOS. Design: We conducted a 12-week prospective randomized open-label study with 30 obese metformin intolerant women with PCOS (aged 35.0+-7.2 years, BMI 36.9+-5.5 kg/m2). After metformin withdrawal they were randomized to lifestyle intervention and sitagliptin 100mg QD (SITA) or lifestyle intervention alone as controls (CON). Methods: All participants underwent anthropometric and endocrine measurements and OGTT. Model derived indexes of insulin resistance (IR) and beta-cell function were calculated. Results: SITA improved beta-cell function as assessed by homeostasis model assessment for beta-cell function index (HOMA-B) for 45.9+-35.8 (p=0.001), modified beta-cell function index (MBCI) for 7.9+-7 (p=0.002) and quantitative insulin sensitivity check index (QUICKI) for -0.03+-0.03 (p=0.002). By contrast, beta-cell function decreased in CON. The between group differences were significant for HOMA-B (p=0.000), MBCI (p=0.010) and QUICKI (p=0.025). The conversion rate to impaired glucose homeostasis was prevented in SITA: 3/15 of subjects had IGT before and after the study. In CON none had T2D and 4 had IGT at the beginning. After 12 weeks IGT was observed in 2 and T2D in 3 subjects. Conclusion: SITA improved beta-cell function and prevented a conversion rate to IGT and T2D in metformin intolerant obese PCOS.
Proste vsebinske oznake		polycystic ovary syndrome DPP4 inhibitor beta-cell function sindrom policističnih jajčnikov DPP4 inhibitor funkcija beta celic