Avtor/Urednik		Grogan, James A.; Connor, Anthony J.; Markelc, Boštjan; Muschel, Ruth J.; Maini, Philip K.; Byrne, Helen; Pitt-Francis, Joe
Naslov		Microvessel chaste
Tip		članek
Vol. in št.		Letnik 112, št. 9
Leto izdaje		2017
Obseg		str. 1767-1772
ISSN		0006-3495 - Biophysical journal
Jezik		eng
Abstrakt		Spatial models of vascularized tissues are widely used in computational physiology. We introduce a software library for composing multiscale, multiphysics models for applications including tumor growth, angiogenesis, osteogenesis, coronary perfusion, and oxygen delivery. Composition of such models is time consuming, with many researchers writing custom software. Recent advances in imaging have produced detailed three-dimensional (3D) datasets of vascularized tissues at the scale of individual cells. To fully exploit such data there is an increasing need for software that allows user-friendly composition of efficient, 3D models of vascularized tissues, and comparison of predictions with in vivo or in vitro experiments and alternative computational formulations. Microvessel Chaste can be used to build simulations of vessel growth and adaptation in response to mechanical and chemical stimuli; intra- and extravascular transport of nutrients, growth factors and drugs; and cell proliferation in complex 3D geometries. In addition, it can be used to develop custom software for integrating modeling with experimental data processing workflows, facilitated by a comprehensive Python interface to solvers implemented in C++. This article links to two reproducible example problems, showing how the library can be used to build simulations of tumor growth and angiogenesis with realistic vessel networks.
Proste vsebinske oznake		mikrožilje onkologija prostorsko modeliranje računalniška fiziologija microvessel oncology spatial modeling computational physiology