Avtor/Urednik		Tibaut, Miha; Petrovič, Danijel
Naslov		Oxidative stress genes, antioxidants and coronary artery disease in type 2 diabetes mellitus
Tip		članek
Vol. in št.		Letnik 14, št. 1
Leto izdaje		2016
Obseg		str. 23-38
ISSN		1871-5257 - Cardiovascular & hematological agents in medicinal chemistry
Jezik		eng
Abstrakt		The worldwide increasing prevalence of obesity and sedentary lifestyle is the main cause of the rising incidence of T2DM. Due to chronic macrovascular and microvascular complications, T2DM represent a huge socioeconomic burden in the world. Oxidative stress is a key pathogenic mechanism implicated in diabetic coronary artery disease (CAD). Polymorphisms of oxidative stress genes are known to influence oxidative stress levels and are therefore thought to impact CAD pathogenesis. Identifying higher risk groups would be rational, since it would allow better sample selection and thus better results in antioxidant trials. In this review, we summarize the evidence of oxidative stress gene polymorphisms related to the pathogenesis of CAD. Moreover, we provide a review of antioxidants tested in subjects with CAD.
Proste vsebinske oznake		antioksidanti koronarna arterija bolezni sladkorna bolezen inzulin antioxidants coronary artery disease diabetes mellitius insulin