Avtor/Urednik		Malenica, M.; Šilar, Mira; Dujić, Tanja; Bego, T.; Semiz, Sabina; Škrbo, Selma; Prnjavorac, Besim; Čaušević, Adlija
Naslov		Importance of inflammatory markers and IL-6 for diagnosis and follow up of patients with type 2 diabetes mellitus
Prevedeni naslov		Značaj inflamatornih markera i IL-6 u dijagnozi i praćenju pacijenata s dijabetes melitusom tipa 2
Tip		članek
Vol. in št.		Letnik 14, št. 2
Leto izdaje		2017
Obseg		str. 169-175
ISSN		1840-0132 - Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina
Jezik		eng
Abstrakt		Aim To analyse the long-term impact of altered metabolism on the level of mediators of inflammatory response in female patients with type 2 diabetes. Methods This study included 97 female patients with type 2 diabetes and 107 female, nondiabetic control subjects, who were recruited at the Clinical Centre University of Sarajevo and the General Hospital Tešanj. The effects of glycaemic control on markers of inflammatory response represented by C-reactive protein (CRP), fibrinogen, leukocytes, sedimentation rate, and cytokine IL-6 were tested. All subjects were free of evidence of infections, surgery, thyroid disease, polycystic ovarian syndrome, active liver and kidney damage. All biochemical analyses were performed according to standard International Federation of Clinical Chemistry (IFCC) protocols. Results A significant increase of fibrinogen (p<0.001), CRP (p=0.001), interleukin-6 (p=0.013), leukocytes (p<0.001) and sedimentation rate (p=0.008) in diabetic female population compared to control subjects was found. A significant correlation between CRP and haemoglobin A1c (p=0.035), interleukin-6 and glucose (p=0.032), IL-6 and body mass index (p=0.007) was found. Conclusion Our data suggest that inflammation plays an important role in the pathogenesis of diabetes in female diabetic population. A more detailed study on a far larger number of subjects is needed if they were to be used effectively as biomarkers in the primary prevention of type 2 diabetes in this population.
Proste vsebinske oznake		vnetni markerji sladkorna bolezen tip 2 spremljanje bolnikov inflammatory markers type 2 diabetes mellitus follow up of patients