Avtor/Urednik		Kališnik, Jurij-Matija; Hrovat, Eva; Hrastovec, Alenka; Žibert, Janez; Jerin, Aleš; Skitek, Milan; Santarpino, Giuseppe; Klokočovnik, Tomislav
Naslov		Creatinine, neutrophil gelatinase-associated lipocalin, and cystatin C in determining acute kidney injury after heart operations using cardiopulmonary bypass
Tip		članek
Vol. in št.		Letnik iss. 5, št. Vol. 41
Leto izdaje		2017
Obseg		str. 481-489
ISSN		1525-1594 - Artificial organs
Jezik		eng
Abstrakt		Acute kidney injury (AKI) represents frequent complication after cardiac surgery using cardiopulmonary bypass (CPB). In the hope to enhance earlier more reliable characterization of AKI, we tested the utility of neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C (CysC) in addition to standard creatinine for early determination of AKI after cardiac surgery using CPB. Forty-one patients met the inclusion criteria. Arterial blood samples collected after induction of general anesthesia were used as baseline, further sampling occurred at CPB termination, 2 h after CPB, on the first and second day after surgery. According to AKIN classification 18 patients (44%) developed AKI (AKI1-2 groups) and 23 (56%) did not (non-AKI group). Groups were similar regarding demographics and operative characteristics. CysC levels differed already preoperatively (non-AKI vs. AKI2; P=0.045; AKI1 vs. AKI2; P=0.011), while postoperatively AKI2 group differed on the first day and AKI1 on the second regarding non-AKI group (P=0.004; P=0.021, respectively). NGAL and creatinine showed significant difference already 2 h after CPB between groups AKI2 and non-AKI and later on the first postoperative day between groups AKI1 and AKI2 (P=0.028; P= 0.014, respectively). This study shows similar performance of early plasma creatinine and NGAL in patients with preserved preoperative renal function. It demonstrates that creatinine, as well as NGAL, differentiate subsets of patients developing AKI of clinically more advanced grade early after 2 h, also when used single and uncombined.
Proste vsebinske oznake		neutrophil gelatinase-associated lipocalin cystatin C acute kidney injury cardiopulmonary bypass