Avtor/Urednik		Kovač, Valerija; Čurin-Šerbec, Vladka
Naslov		Prion proteins without the glycophosphatidylinositol anchor
Tip		članek
Vol. in št.		, št. Vol. 13
Leto izdaje		2017
Obseg		str. 1-5
ISSN		1177-2719 - Biomarker insights
Jezik		eng
Abstrakt		Prion protein (PrP) is a biomolecule that is involved in neuronal signaling, myelinization, and the development of neurodegenerative diseases. In the cell, PrP is shed by the ADAM10 protease. This process generates PrP molecules that lack glycophosphatidylinositol anchor, and these molecules incorporate into toxic aggregates and neutralize toxic oligomers. Due to this dual role, these molecules are important biomarkers for neurodegenerative diseases. In this review, we present shed PrP as a potential biomarker, with a focus on PrP226*, which may be the main biomarker for predicting neurodegenerative diseases in humans.
Proste vsebinske oznake		Prionska bolezen Alzheimerjeva bolezen nevrodegenerativna bolezen Prion disease Alzheimer disease neurodegenerative disease