Avtor/Urednik     Burja, Blaž; Kuret, Tadeja; Sodin-Šemrl, Snežna; Lakota, Katja; Rotar, Žiga; Ješe, Rok; Mrak Poljšak, Katjuša; Žigon, Polona; Thallinger, Gerhard G.; Feichtinger, J.; Čučnik, Saša; Tomšič, Matija; Praprotnik, Sonja; Hočevar, Alojzija
Naslov     A concise review of significantly modified serological biomarkers in giant cell arteritis, as detected by different methods
Tip     članek
Vol. in št.     Letnik 17, št. 2
Leto izdaje     2018
Obseg     str. 188-194
ISSN     1568-9972 - Autoimmunity reviews
Jezik     eng
Abstrakt     Giant cell arteritis (GCA) is a primary systemic vasculitis present in subjects older than 50 years with involvement of large- and medium-sized arteries. Early diagnosis for GCA is essential to prevent serious complications, such as permanent vision loss and/or cerebrovascular events. Elevated inflammatory cytokines, with acute phase and other proteins dominate large- and medium-sized arteries leading to stenosis or occlusion of arterial lumen. To date, there are no reliable serological markers for monitoring GCA. The review aims to provide concise overview of published GCA studies in order to: a) identify significantly changed serological biomarkers in GCA and compare the influences of techniques for marker evaluation and b) investigate most promising markers in GCA using analyte frequency and meta-analysis.
Proste vsebinske oznake     giant cell arteritis
biomarkers
serology
giant celični arteritis
biomarkerji
serologija