Avtor/Urednik		Haigentz, Missak; Suárez, Carlos; Strojan, Primož; Rodrigo, Juan Pablo; Rinaldo, Alessandra; Bradford, Carol R.; Corry, June; Takes, Robert P.; Ferlito, Alfio
Naslov		Understanding interactions of smoking on prognosis of HPV-associated oropharyngeal cancers
Tip		članek
Vol. in št.		Letnik 35, št. 3
Leto izdaje		2018
Obseg		str. 255-260
ISSN		0741-238X - Advances in therapy
Jezik		eng
Abstrakt		The new 8th edition AJCC/UICC staging system for human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC), developed to account for improved survival outcomes over HPV-negative cancers, includes anatomic features strictly associated with tumor-node-metastasis (TNM) and does not account for patient-specific characteristics that may impact prognosis. This commentary evaluates the evidence of smoking as an adverse prognostic factor in HPV-associated OPSCC. We review the multifactorial biological, clinical, and social/behavioral characteristics of smokers with OPSCC that impact outcomes, discuss current challenges with incorporating smoking history in prognostic classifications, and consider opportunities for future investigation.
Proste vsebinske oznake		rak glave in vratu HPV humani papilomski virus orofaringealni ploščatocelični rak head and neck cancer HPV OPSCC oropharyngeal squamous cell carcinoma