Avtor/Urednik		Bukleta, Dashnor; Krasniqi, Shaip; Beretta, Giangiacomo; Nila, Arb; Komoni, Teuta; Selmani-Bukleta, Manushaqe; Schara, Rok
Naslov		Impact of combined non-surgical and surgical periodontal treatment in patients with type 2 diabetes mellitus - a preliminary report randomized clinical study
Tip		članek
Vol. in št.		Letnik 29, št. 3
Leto izdaje		2018
Obseg		str. 1-7
ISSN		0970-938X - Biomedical Research
Jezik		eng
Abstrakt		Background/objectives: Scientific evidence regarding the effects of chronic periodontitis on Type 2 Diabetes Mellitus (T2M) is fragmentary and not definitive. This intervention study was designed to evaluate the effects of a Non-Surgical Procedure (NSP) in addition to a surgical procedure on systemic inflammation and glycaemic control in patients with T2M and periodontitis and Non-Diabetic (ND) patients with periodontitis. Material and Methods: A total of 100 patients with diabetes were randomly allocated to a treatment group and a control group. At least one tooth was extracted from each patient. After extraction, the control group (n=50) did not receive any other treatment until the 3-month follow-up. Patients in the treatment group (n=50) received Full-Mouth Scaling and Root Planing (FM-SRP).The Mean Probing Depth (MPD), Mean Attachment Level (MAL), Plaque Index (PI), Bleeding on Probing (BOP), fasting blood samples for the measurement of high-sensitivity C-Reactive Protein (hs-CRP), and glycated hemoglobin (HbA1c) were measured or taken at baseline and 3 months after treatment. To investigate the effect of diabetes on the therapeutic procedure's outcome, ND patients with periodontitis (n=60) were divided into two equal groups and subjected to the same procedures and analysis. Results: HbA1c and hs-CRP decreased significantly in the diabetic groups and decreased more markedly when FM-SRP was added to tooth extraction (P<0.001). For ND patients, all of the examined periodontal parameters were in favor of the combination therapy (P<0.001). Conclusion: Non-surgical periodontal treatment can help improve the outcome of surgical periodontal procedures by reducing systemic inflammatory status and improve glucose metabolism.
Proste vsebinske oznake		diabetes mellitus type 2 inflammation periodontitis sladkorna bolezen tip 2 vnetje periodontitis