Avtor/Urednik		Loisel, Fanny; Provost, Bastien; Haddad, François; Guihaire, Julien; Amsallem, Myriam; Vrtovec, Bojan; Fadel, Elie; Uzan, Georges; Mercier, Olaf
Naslov		Stem cell therapy targeting the right ventricle in pulmonary arterial hypertension
Tip		članek
Vol. in št.		Letnik 8, št. 2
Leto izdaje		2018
Obseg		str. 1-17
ISSN		2045-8940 - Pulmonary circulation
Jezik		eng
Abstrakt		Pulmonary arterial hypertension (PAH) is an incurable disease characterized by an increase in pulmonary arterial pressure due to pathological changes to the pulmonary vascular bed. As a result, the right ventricle (RV) is subject to an increased afterload and undergoes multiple changes, including a decrease in capillary density. All of these dysfunctions lead to RV failure. A number of studies have shown that RV function is one of the main prognostic factors for PAH patients. Many stem cell therapies targeting the left ventricle are currently undergoing development. The promising results observed in animal models have led to clinical trials that have shown an improvement of cardiac function. In contrast to left heart disease, stem cell therapy applied to the RV has remained poorly studied, even though it too may provide a therapeutic benefit. In this review, we discuss stem cell therapy as a treatment for RV failure in PAH. We provide an overview of the results of preclinical and clinical studies for RV cell therapies. Although a large number of studies have targeted the pulmonary circulation rather than the RV directly, there are nonetheless encouraging results in the literature that indicate that cell therapies may have a direct beneficial effect on RV function. This cell therapy strategy may therefore hold great promise and warrants further studies in PAH patients.
Proste vsebinske oznake		pulmonary arterial hypertension progenitor cells stem cells pljučna arterijska hipertenzija progenitorne celice izvorne celice