Avtor/Urednik		Rožman, Primož
Naslov		The potential of non-myeloablative heterochronous autologous hematopoietic stem cell transplantation for extending a healthy life span
Tip		članek
Leto izdaje		2018
Obseg		str. str.
Jezik		eng
Abstrakt		Aging is a complex multifactorial process, a prominent component being the senescence of the immune system. Consequently, immune-related diseases develop, including atherosclerosis, cancer, and life-threatening infections, which impact on health and longevity. Rejuvenating the aged immune system could mitigate these diseases, thereby contributing to longevity and health. Currently, an appealing option for rejuvenating the immune system is heterochronous autologous hematopoietic stem cell transplantation (haHSCT), where healthy autologous bone marrow/peripheral blood stem cells are collected during the youth of an individual, cryopreserved, and re-infused when he or she has reached an older age. After infusion, young hematopoietic stem cells can reconstitute the compromised immune system and improve immune function. Several studies using animal models have achieved substantial extension of the life span of animals treated with haHSCT. Therefore, haHSCT could be regarded as a potential procedure for preventing age-related immune defects and extending healthy longevity. In this review, the pros, cons, and future feasibility of this approach are discussed.
Proste vsebinske oznake		immune-related diseases of old age longevity stem cell bolezni starosti, povezani z imunskim sistemom dolgoživost matične celice