Avtor/Urednik		Zorec, Tomaž Mark; Kutnjak, Denis; Hošnjak, Lea; Kušar, Blanka; Trčko, Katarina; Kocjan, Boštjan; Li, Yu; Križmarić, Miljenko; Ravnikar, Maja; Poljak, Mario
Naslov		New insights into the evolutionary and genomic landscape of molluscum contagiosum virus (MCV) based on nine MCV1 and six MCV2 complete genome sequences
Tip		članek
Vol. in št.		Letnik 10, št. 11
Leto izdaje		2018
Obseg		str. 1-24
ISSN		1999-4915 - Viruses
Jezik		eng
Abstrakt		Molluscum contagiosum virus (MCV) is the sole member of the Molluscipoxvirus genus and the causative agent of molluscum contagiosum (MC), a common skin disease. Although it is an important and frequent human pathogen, its genetic landscape and evolutionary history remain largely unknown. In this study, ten novel complete MCV genome sequences of the two most common MCV genotypes were determined (five MCV1 and five MCV2 sequences) and analyzed together with all MCV complete genomes previously deposited in freely accessible sequence repositories (four MCV1 and a single MCV2). In comparison to MCV1, a higher degree of nucleotide sequence conservation was observed among MCV2 genomes. Large-scale recombination events were identified in two newly assembled MCV1 genomes and one MCV2 genome. One recombination event was located in a newly identified recombinant region of the viral genome, and all previously described recombinant regions were re-identified in at least one novel MCV genome. MCV genes comprising the identified recombinant segments have been previously associated with viral interference with host T-cell and NK-cell immune responses. In conclusion, the two most common MCV genotypes emerged along divergent evolutionary pathways from a common ancestor, and the differences in the heterogeneity of MCV1 and MCV2 populations may be attributed to the strictness of the constraints imposed by the host immune response.
Proste vsebinske oznake		molluscum contagiosum virus complete genome recombination virus molluscum contagiosum popolni genom rekombinacija