Avtor/Urednik		Strojan, Primož; Zakotnik, Branko; Žumer, Barbara; Karner, Katarina Barbara; Dremelj, Marta; Jančar, Boris; Jereb, Simona; Grašič-Kuhar, Cvetka
Naslov		Skin reaction to cetuximab as a criterion for treatment selection in head and neck cancer
Tip		članek
Vol. in št.		Letnik 38, št. 7
Leto izdaje		2018
Obseg		str. 4213-4220
ISSN		0250-7005 - Anticancer research
Jezik		eng
Abstrakt		BACKGROUND/AIM: It can be hypothesized that in patients with locally advanced head and neck cancer and prominent cetuximab (CMb)-induced skin rash, immunoradiotherapy would result in a survival advantage over chemoradiotherapy with cisplatin (CP). PATIENTS AND METHODS: After a loading dose of CMb, one weekly cycle of CMb and CP concurrently with RT, patients who developed a grade %2 rash proceeded with immunoradiotherapy, and those with a grade 0-1 rash had chemoradiotherapy. RESULTS: A grade 3-4 allergic reaction to CMb developed in 11/39 (28.2%) patients and further recruitment was stopped. These patients proceeded treatment with CP. In early assessment of skin rash 10/28 patients qualified for chemoradiotherapy and 18/28 patients for immunoradiotherapy. There was no difference in survival between the two groups. CONCLUSION: Rate of serious CMb-induced hypersensitivity reactions was unacceptably high. Even though immunoradiotherapy was administered only to the prognostically most favorable group of patients, it resulted in no advantage over chemoradiotherapy.
Proste vsebinske oznake		rak glave in vratu kožni izpuščaji bioradioterapija kemoradioterapija head and neck cancer skin rash bioradiotherapy chemoradiotherapy