Avtor/Urednik		Shan, Ling; Bao, Ai-Min; Swaab, Dick Frans
Naslov		The human histaminergic system in neuropsychiatric disorders
Tip		članek
Vol. in št.		Letnik 38, št. 3
Leto izdaje		2015
Obseg		str. 167-177
ISSN		0166-2236 - Trends in Neurosciences
Jezik		eng
Abstrakt		Histaminergic neurons are exclusively located in the hypothalamic tuberomamillary nucleus, from where they project to many brain areas. The histaminergic system is involved in basic physiological functions, such as the sleep-wake cycle, energy and endocrine homeostasis, sensory and motor functions, cognition, and attention, which are all severely affected in neuropsychiatric disorders. Here, we present recent postmortem findings on the alterations in this system in neuropsychiatric disorders, including Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), depression, and narcolepsy. In addition, we highlight the need to validate animal models for these diseases and also for Tourette's syndrome (TS) in relation to alterations in the histaminergic system. Moreover, we discuss the potential for, and concerns over, the use of novel histamine 3 receptor (H3R) antagonists/inverse agonists as treatment for such disorders.
Proste vsebinske oznake		Parkinson's disease Alzheimer's disease narcolepsy Parkinsonova bolezen Alzheimerjeva bolezen narkolepsija