Avtor/Urednik		Kastrin, Andrej; Hristovski, Dimitar
Naslov		Disentangling the evolution of MEDLINE bibliographic database
Tip		članek
Vol. in št.		, št. Vol. 89
Leto izdaje		2019
Obseg		str. 101-113
ISSN		1532-0464 - Journal of biomedical informatics
Jezik		eng
Abstrakt		Scientific knowledge constitutes a complex system that has recently been the topic of in-depth analysis. Empirical evidence reveals that little is known about the dynamic aspects of human knowledge. Precise dissection of the expansion of scientific knowledge could help us to better understand the evolutionary dynamics of science. In this paper, we analyzed the dynamic properties and growth principles of the MEDLINE bibliographic database using network analysis methodology. The basic assumption of this work is that the scientific evolution of the life sciences can be represented as a list of co-occurrences of MeSH descriptors that are linked to MEDLINE citations. The MEDLINE database was summarized as a complex system, consisting of nodes and edges, where the nodes refer to knowledge concepts and the edges symbolize corresponding relations. We performed an extensive statistical evaluation based on more than 25 million citations in the MEDLINE database, from 1966 until 2014. We based our analysis on node and community level in order to track temporal evolution in the network. The degree distribution of the network follows a stretched exponential distribution which prevents the creation of large hubs. Results showed that the appearance of new MeSH terms does not also imply new connections. The majority of new connections among nodes results from old MeSH descriptors. We suggest a wiring mechanism based on the theory of structural holes, according to which a novel scientific discovery is established when a connection is built among two or more previously disconnected parts of scientific knowledge. Overall, we extracted 142 different evolving communities. It is evident that new communities are constantly born, live for some time, and then die. We also provide a Web-based application that helps characterize and understand the content of extracted communities. This study clearly shows that the evolution of MEDLINE knowledge correlates with the network's structural and temporal characteristics.
Proste vsebinske oznake		complex networks bibliographic databases MEDLINE kompleksna omrežja bibliografske zbirke podatkov MEDLINE