Avtor/Urednik		Sikirić, Predrag; Seiwerth, Sven; Ručman, Rudolf; Turkovic, Branko; Stancic-Rokotov, Dinko; Brcic, Luka; Sever, Marko; Klicek, Robert; Radic, Bozo; Kolenc, Danijela
Naslov		Stable gastric pentadecapeptide BPC 157-NO-system relation
Tip		članek
Vol. in št.		Letnik iss. 7, št. Vol. 20
Leto izdaje		2014
Obseg		str. 1126-1135
ISSN		1381-6128 - Current pharmaceutical design
Jezik		eng
Abstrakt		We reviewed stable gastric pentadecapeptide BPC 157-NO-system-relation, its close participation in Moncada's (maintained vascular integrity, platelets control) homeostatic healing response of NO-system to injury. Namely, BPC 157%s particular healing effect also affects all events after vascular integrity loss (dependent on circumstances, it reduces either thrombosis (abdominal aorta anastomosis) or bleeding/thrombocytopenia (amputation, heparin, warfarin, aspirin)) and in a series of different injurious models, acute and chronic, BPC 157 consistently advances healing after severe injuries in various tissues spontaneously unable to heal; stimulates egr-1 and naB2 genes; exhibits high safety (LD1 not achieved)). Hypothesis, that BPC 157 (since formed constitutively in the gastric mucosa, stable in human gastric juice, along with significance of NO-synthase and the basal formation of NO in stomach mucosa, greater than that seen in other tissues) exhibits a general, effective competing both with L-arginine analogues (i. e., L-NAME) and L-arginine, and that this has some physiologic importance (NO-generation), later, practically supports its beneficial effects illustrating BPC 157 and NOsystem mutual (with L-NAME/L-arginine; alone and together) relations in (i) gastric mucosa and mucosal protection, following alcohol lesions, in cytoprotection course, NO-generation, and blood pressure regulation; (ii) alcohol acute/chronic intoxication, and withdrawal; (iii) cardiovascular disturbances, chronic heart failure, pulmonary hypertension, and arrhythmias; (iv) disturbances after hypokalemia and hyperkalemia, and potassium-cell membrane dysfunction; and finally, in (v) complex healing failure, proved by the fistulas healing, colocutaneous and esophagocutaneous. However, how this advantage of modulating NO-system (i. e., particular effect on eNOS gene), may be practically translated into an enhanced clinical performance remains to be determined.
Proste vsebinske oznake		arrhythmias chronic heart failure pentadecapeptide BPC 157 aritmije kronična srčna odpoved pentadekaptid BPC 157