Avtor/Urednik		Zivkovic, Morana; Poljak-Blazi, Marija; Žarković, Kamelija; Kolenc, Danijela; Schaurc, Rudolf Joerg; Žarković, Neven
Naslov		Oxidative burst of neutrophils against melanoma B16-F10
Tip		članek
Vol. in št.		Letnik 246, št. 1/2
Leto izdaje		2007
Obseg		str. 100-108
ISSN		0304-3835 - Cancer letters
Jezik		eng
Abstrakt		Intensive oxidative burst was determined by chemiluminescence of peripheral blood neutrophils of mice that were intramuscularly injected with melanoma B16-F10 and/or subcutaneously with Sephadex G-200. The neutrophils from papula developed at the site of Sephadex injection were cytotoxic for the B16-F10 cells in vitro. However, survival of Sephadex injected tumour-bearing mice was lower than of control animals bearing B16-F10, while their tumours grew faster and were less necrotic. Thus, it is likely that injection of Sephadex distracted the neutrophils from the tumour allowing faster progression of the tumour, indicating that neutrophils may have an important role in the host defence against malignant cells in the early stage of tumour development.
Proste vsebinske oznake		melanoma B16-F10 neutrophils polymorphonuclear leukocytes melanom B16-F10 neutrofili polimorfonuklearni levkociti