Avtor/Urednik		Stargardt, Anita; Swaab, Dick Frans; Bossers, Koen
Naslov		The storm before the quiet
Tip		članek
Vol. in št.		Letnik 36, št. 1
Leto izdaje		2014
Obseg		str. 1-11
ISSN		0197-4580 - Neurobiology of aging
Jezik		eng
Abstrakt		Neuronal activity directly promotes the production and secretion of amyloid [beta] (A[beta]). Interestingly, neuronal hyperactivity can be observed in presymptomatic stages of both sporadic and familial Alzheimer's disease (AD) and in several AD mouse models. In this review, we will highlight the recent evidence for neuronal hyperactivity before or during the onset of cognitive defects in mild cognitive impairment. Furthermore, we review specific molecular mechanisms through which neuronal hyperactivity affects A[beta] production and degradation. With these data, we will provide more insight into the 2-faced nature of neuronal hyperactivity: does enhanced neuronal activity during the presymptomatic stages of AD provide protection against the earliest disease processes or is it a pathogenic contributor to AD?
Proste vsebinske oznake		Alzheimer's disease neuronal hyperactivity synaptotoxicity Alzheimerjeva bolezen nevronska hiperaktivnost sinaptotoksičnost