Avtor/Urednik		Qi, Xin-Rui; Zhao, Jun; Liu, Ji; Fang, Hui; Swaab, Dick Frans; Zhou, Jiang-Ning
Naslov		Abnormal retinoid and TrkB signaling in the prefrontal cortex in mood disorders
Tip		članek
Vol. in št.		Letnik 25, št. 1
Leto izdaje		2015
Obseg		str. 75-83
ISSN		1047-3211 - Cerebral cortex (New York, N.Y. : 1991)
Jezik		eng
Abstrakt		The prefrontal cortex shows structural and functional alterations inmood disorders. Retinoid signaling, brain-derived neurotrophic factor(BDNF), and its receptor TrkB are reported to be involved in depression. Here, we found that mRNA levels of key elements of retinoid signaling were significantly reduced in the postmortem dorsolateral prefrontal cortex/anterior cingulate cortex (ACC) from elderly depressed patients who did not die from suicide. Decreased mRNAlevels of BDNF and TrkB isoforms were also found. Similar alterations were observed in rats subjected to chronic unpredictable mildstress. Along with neurons immunopositive for both retinoic acid receptor-[alpha](RAR[alpha]) and TrkB, a positive correlation between mRNAlevels of the 2 receptors was found in the ACC of control subjects but not of depressed patients. In vitro studies showed that RAR[alpha]was able to bind to and transactivate the TrkB promoter via a putative RA response element within the TrkB promoter. In conclusion,the retinoid and BDNF-TrkB signaling in the prefrontal cortex are compromised in mood disorders, and the transcriptional upregulation of TrkB by RAR[alpha]provide a possible mechanism for their interaction.The retinoid signaling pathway that may activate TrkB expression will be an alternative novel target for BDNF-based antidepressant treatment.
Proste vsebinske oznake		prednji cingularni korteks možganski nevrotrofični faktor dorzolateralni prefrontalni korteks anterior cingulate cortex brain-derived neurotrophic factor dorsolateral prefrontal cortex