Avtor/Urednik		Meer, Thomas P. van der; Artacho-Cordón, Francisco; Swaab, Dick Frans; Struik, Dicky; Makris, Konstantinos C.; Wolffenbuttel, Bruce H. R.; Frederiksen, Hanne; Vliet-Ostaptchouk, Jana V. van
Naslov		Distribution of non-persistent endocrine disruptors in two different regions of the human brain
Tip		članek
Vol. in št.		Letnik 14, št. 9
Leto izdaje		2017
Obseg		str. 1-11
ISSN		1660-4601 - International journal of environmental research and public health
Jezik		eng
Abstrakt		Non-persistent endocrine disrupting chemicals (npEDCs) can affect multiple organs andsystems in the body. Whether npEDCs can accumulate in the human brain is largely unknown.The major aim of this pilot study was to examine the presence of environmental phenols and parabensin two distinct brain regions: the hypothalamus and white-matter tissue. In addition, a potentialassociation between these npEDCs concentrations and obesity was investigated. Post-mortem brainmaterial was obtained from 24 individuals, made up of 12 obese and 12 normal-weight subjects(defined as body mass index (BMI) > 30 and BMI < 25 kg/m2, respectively). Nine phenols and sevenparabens were measured by isotope dilution TurboFlow-LC-MS/MS. In the hypothalamus, sevensuspect npEDCs (bisphenol A, triclosan, triclocarban and methyl-, ethyl-, n-propyl-, and benzylparaben) were detected, while five npEDCs (bisphenol A, benzophenone-3, triclocarban, methyl-,and n-propyl paraben) were found in the white-matter brain tissue. We observed higher levelsof methylparaben (MeP) in the hypothalamic tissue of obese subjects as compared to controls(p =0.008). Our findings indicate that some suspected npEDCs are able to cross the blood-brainbarrier. Whether the presence of npEDCs can adversely affect brain function and to which extent thedetected concentrations are physiologically relevant needs to be further investigated.
Proste vsebinske oznake		možgani hipotalamus debelost brain hypothalamus obesity