Avtor/Urednik | Zimet, Zlatko; Bilban, Marjan; Osredkar, Joško; Poljšak, Borut; Fabjan, Teja; Kumer, Kristina | |
Naslov | Three day environmental exposure may trigger oxidative stress development and provoke adaptive response resulting in altered antioxidant activity | |
Tip | članek | |
Vol. in št. | Letnik 48, št. 7 | |
Leto izdaje | 2019 | |
Obseg | str. 1284-1291 | |
ISSN | 2251-6085 - Iranian journal of public health | |
Jezik | eng | |
Abstrakt | We aimed to investigate the polluted working environment triggers oxidative stress and alter enzymatic antioxidant activity by a short-term interval. Methods: The experimental study, performed in 2014, involved 94 workers from the Velenje Coalmine in Slovenia, arranged into three groups according to a number of consecutive working days in a mineshaft, supported by a control group. Levels of the antioxidant enzymes (GPx, CAT, SOD) together with TAC (the combined effect of all antioxidants) and 8-isoprostane (a biological marker of oxidative stress/damage) were measured in human plasma. Results: Workers occupationally exposed for three consecutive working days had significantly increased 8-isoprostane biomarker, a parameter of oxidative stress (P<0.001). The antioxidant levels of TAC (P<0.001), CAT (P<0.001) and SOD (P<0.001) were all significantly decreased compared to a control group. Conclusion: Workers in polluted working environment had significantly increased oxidative stress and altered antioxidant activity already on a third consecutive working day. | |
Deskriptorji | Oksidativni stres Okolje | |
Proste vsebinske oznake | polluted working environment oxidative stress 8-isoprostane enzymatic antioxidant activity |