Avtor/Urednik		Ferjan, Simona; Jensterle Sever, Mojca; Oblak, Tjaša; Prodan Žitnik, Irena; Marc, Janja; Goričar, Katja; Dolžan, Vita; Janež, Andrej
Naslov		An impaired glucagon-like peptide-1 response is associated with prediabetes in polycystic ovary syndrome with obesity
Tip		članek
Vol. in št.		Letnik 47, št. 10
Leto izdaje		2019
Obseg		str. 4691-4700
ISSN		0300-0605 - Journal of international medical research
Jezik		eng
Abstrakt		Objective Impaired glucose homeostasis in polycystic ovary syndrome (PCOS) is associated with obesity, age, and disease phenotype. This study aimed to investigate the glucagon-like peptide-1 (GLP-1) response in patients with obesity and PCOS with normal glucose tolerance (NGT) or prediabetes. Methods Twenty-six women with obesity and PCOS were included. Thirteen women had NGT and 13 had prediabetes. Serum glucose, insulin, and GLP-1 levels were measured during an oral glucose tolerance test. Beta-cell function and insulin resistance were determined. Results Women with prediabetes had significantly lower GLP-1 levels than did those with NGT after a glucose load. GLP-1 levels <3.02%pM at 120 minutes were associated with prediabetes. Women with prediabetes had a lower oral glucose insulin sensitivity (OGIS) index and greater amount of visceral adipose tissue than did those with NGT. Plasma GLP-1 levels at 120 minutes were correlated with visceral adiposity and the OGIS index. A change in GLP-1 levels was correlated with a family history of type 2 diabetes. Conclusion The GLP-1 response is lower in patients with obesity, PCOS, and prediabetes than in those with obesity, PCOS, and NGT. Further investigation of the GLP-1 response as a potential separate risk factor for prediabetes in PCOS is required.
Deskriptorji		Debelost Sindrom policističnega ovarija Diabetes
Proste vsebinske oznake		prediabetes obesity polycistic ovary syndrome glucagon-like peptide-1 (GLP-1) response normal glucose tolerance insulin