Avtor/Urednik		Pavlović, Ivan; Khateb, Soliman; Milisav, Irina; Mahajna, Jamal
Naslov		Nutraceuticals for promoting longevity
Tip		članek
Vol. in št.		Letnik 1, št. 1
Leto izdaje		2020
Obseg		str. 18-32
ISSN		2665-9786
Jezik		eng
Abstrakt		Objective: To summarize the main findings on nutraceuticals that slow aging processes by delaying and even preventing the development of multiple chronic diseases and improve productivity and quality of life in the elderly. Methods: Literature search of the relevant papers known to the authors was conducted. Results: The most robust environmental manipulation for extending lifespan is caloric restriction without malnutrition. Some nutraceuticals can mimic caloric restriction effects. This review will focus on the nutraceuticals that impact insulin-like growth factor 1 receptor signaling and sirtuin activity in mediating longevity and healthspan. Conclusion: Aging is considered to be synonymous with the appearance of major diseases and an overall decline in physical and mental performance. Caloric restriction is well established as a strategy to extend lifespan without malnutrition. A variety of nutraceuticals were reported to mimic the effect of caloric restriction by modulating the activity of insulin-like growth factor 1 receptor signaling and sirtuin activity and consequently promote longevity and healthspan.
Proste vsebinske oznake		Nutraceuticals kalorična omejitev inzulinu podoben receptor rastnega faktorja 1 (IGF1R) Nutraceuticals caloric restriction insulin-like growth factor 1 receptor (IGF1R)