Avtor/Urednik		Dariš, Barbara; Knez, Željko
Naslov		Poly(3-hydroxybutyrate)
Tip		članek
Vol. in št.		Letnik 70, št. 1
Leto izdaje		2020
Obseg		str. 1-15
ISSN		1846-9558 - Acta pharmaceutica (Zagreb, Croatia)
Jezik		eng
Abstrakt		Poly(3-hydroxybutyrate) is a natural polymer, produced by different bacteria, with good biocompatibility and biodegradability. Cardiovascular patches, scaffolds in tissue engineering and drug carriers are some of the possible biomedical applications of poly(3-hydroxybutyrate). In the past decade, many researchers examined the different physicochemical modifications of poly(3-hydroxybutyrate) in order to improve its properties for use in the field of bone tissue engineering. Poly(3-hydroxybutyrate) composites with hydroxyapatite and bioglass are intensively tested with animal and human osteoblasts in vitro to provide information about their biocompatibility, biodegradability and osteoinductivity. Good bone regeneration was proven when poly(3-hydroxybutyrate) patches were implanted in vivo in bone tissue of cats, minipigs and rats. This review summarizes the recent reports of in vitro and in vivo studies of pure poly(3-hydroxybutyrate) and poly(3-hydroxybutyrate) composites with the emphasis on their bioactivity and biocompatibility with bone cells.
Proste vsebinske oznake		poly(3-hydroxybutyrate) biopolymers bone tissue engineering osteoblasts