Avtor/Urednik		Comte, Blandine; Baumbach, Jan; Benis, Arriel; Basilio, José; Debeljak, Nataša; Flobak, Åsmund; Franken, Christian; Harel, Nissim; Režen, Tadeja; Rozman, Damjana
Naslov		Network and systems medicine
Tip		članek
Vol. in št.		Letnik 3, št. 1
Leto izdaje		2020
Obseg		str. 67-90
ISSN		2690-5949
Jezik		eng
Abstrakt		Introduction:Network and systems medicine has rapidly evolved over the past decade, thanks to computa-tional and integrative tools, which stem in part from systems biology. However, major challenges and hurdlesare still present regarding validation and translation into clinical application and decision making for precisionmedicine.Methods:In this context, the Collaboration on Science and Technology Action on Open Multiscale SystemsMedicine (OpenMultiMed) reviewed the available advanced technologies for multidimensional data generationand integration in an open-science approach as well as key clinical applications of network and systems med-icine and the main issues and opportunities for the future.Results:The development of multi-omic approaches as well as new digital tools provides a unique opportunityto explore complex biological systems and networks at different scales. Moreover, the application of findable,applicable, interoperable, and reusable principles and the adoption of standards increases data availabilityand sharing for multiscale integration and interpretation. These innovations have led to the first clinical applica-tions of network and systems medicine, particularly in the field of personalized therapy and drug dosing. Enlarg-ing network and systems medicine application would now imply to increase patient engagement and healthcare providers as well as to educate the novel generations of medical doctors and biomedical researchers to shift the current organ- and symptom-based medical concepts toward network- and systems-based ones formore precise diagnoses, interventions, and ideally prevention.Conclusion:In this dynamic setting, the health care system will also have to evolve, if not revolutionize, in termsof organization and management.
Proste vsebinske oznake		celostno zdravstveno varstvo sistemska medicina integracija podatkov integrated health care systems medicine data integration