Avtor/Urednik		Urbančič, Mojca; Korošec, Peter; Fležar, Matjaž; Globočnik Petrovič, Mojca
Naslov		Diabetična retinopatija kot subklinično vnetje
Prevedeni naslov		Diabetic retinopathy as a subclinical inflammation
Tip		članek
Vol. in št.		Letnik 89, št. 5/6
Leto izdaje		2020
Obseg		str. 243-254
ISSN		1318-0347 - Zdravniški vestnik : glasilo Slovenskega zdravniškega društva : Slovenian medical journal
Jezik		slv
Abstrakt		Background: Diabetic retinopathy can be defined as chronic subclinical inflammation. The purpose of this study was to investigate levels of inflammatory cytokines in the vitreous and serum of patients with proliferative diabetic retinopathy (PDR) and of control group. In addition, the purpose was to evaluate the levels of cytokines with regard to the activity of PDR. A better understanding of intraocular inflammation in patients with PDR could lead to the development of new treatment options for these patients. Methods: 37 patients with PDR (37 eyes) that required vitrectomy were included in the study. Twenty patients with idiopathic macular hole (MH) served as a control group. The activity of PDR was defined based on preoperative examination and intraoperative evaluation of the fundus. Cytometric Bead Array (CBA) method was used for cytokine analysis. Cytokines interleukin-1% (IL-1%), tumor necrosis factor-% (TNF-%), macrophage inflammatory protein-1% (MIP-1%), macrop - hage inflammatory protein-1% (MIP-1%), monocyte chemoattractant protein-1 (MCP-1), vascular endothelial growth factor (VEGF), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10) and interleukin-12 (IL-12) were analysed in vitreous and serum samples. Results: Levels of all cytokines in the vitreous differed significantly from levels in the serum. Levels of MCP-1, VEGF, IL-6, IL-8 were significantly higher in the vitreous of patients with PDR in comparison with vitreous levels in the control group. Vitreous levels of MIP-1%, IL-10 and IL-12 in patients with PDR were significantly lower in comparison with the control group (p < 0.05). Se - rum levels of cytokines were similar in both groups. Patients with active PDR had higher vitreous levels of MCP-1,VEGF, IL-6 and IL-8 in comparison with patients with inactive disease, although the differences were not significant. Conclusion: Significant differences in cytokine levels in the vitreous compared to serum levels in patients with PDR indicate the importance of local intraocular inflammation. Higher levels of MCP-1, VEGF, IL-6 and IL-8 might reflect the activity of PDR.
Proste vsebinske oznake		diabetična retinopatija vnetje citokini diabetic retinopathy inflammation cytokines