Avtor/Urednik		Perše, Martina; Unkovič, Ana
Naslov		The role of TNF in the pathogenesis of inflammatory bowel disease
Tip		članek
Vir		In: Biological therapy for inflammatory bowel disease London, UK : IntechOpen
Leto izdaje		2020
Obseg		str. 23-35
Jezik		eng
Abstrakt		Tumor necrosis factor (TNF) is a pleotropic cytokine involved in a wide range of pathological processes, including inflammatory bowel disease (IBD). In the past, TNF was recognized as a pro-inflammatory cytokine with deleterious effects. This has led to the development of anti-TNF drugs, which revolutionized the treatment of inflammatory disorders such as Crohn's disease. However, in the past 20 years, clinical studies have shown that anti-TNF drugs are not always effective. Moreover, in some rare cases, anti-TNF drugs can even cause an aggravation of the disease. Nowadays, there is increasing evidence that TNF is not only detrimental but can also play an important role in health and the maintenance of homeostasis. The aim of this chapter is to briefly summarize the literature demonstrating the complex dichotomous role of TNF in IBD and discuss the role of anti-TNF drugs in the treatment of IBD.
Proste vsebinske oznake		faktor tumorske nekroze vnetna črevesna bolezen neželeni učinki tumor necrosis factor inflammatory bowel disease side effects