Avtor/Urednik		Badovinac, Maja; Nadrah, Kristina; Harlander, Matevž
Naslov		Vloga makrolidnih antibiotikov pri zdravljenju kroničnih pljučnih bolezni
Prevedeni naslov		Role of macrolide antibiotics in the treatment of chronic pulmonary diseases
Tip		članek
Vol. in št.		Letnik 89, št. 7/8
Leto izdaje		2020
Obseg		str. 446-457
ISSN		1318-0347 - Zdravniški vestnik : glasilo Slovenskega zdravniškega društva : Slovenian medical journal
Jezik		slv
Abstrakt		Chronic lung diseases are among the leading causes of morbidity and mortality. Despite adequate therapy, some patients fail to fully respond to treatment. Macrolide antibiotics are becoming one of the standard treating options in chronic pulmonary diseases, owing to their anti-inflammatory and antibiotic effects. Firstly, they minimise the adherence and mobility of the bacteria and affect biofilm formation. Secondly, they influence the expression of tight junction proteins and change the mucus composition. They increase antimicrobial susceptibility of bacteria when used in combination with other antibiotics. Beneficial effects on the quality of life and on the number of acute exacerbations in airways diseases have been described. Nonetheless, adverse effects have to be considered. Most importantly, appropriate selection of patients is necessary because long-term use of macrolide antibiotics promotes bacterial resistance in general population.
Proste vsebinske oznake		makrolidni antibiotiki KOPB astma macrolide antibiotics COPD asthma