Avtor/Urednik		Peterlin, Ana Marija; Počivavšek, Karolina; Petrovič, Danijel; Peterlin, Borut
Naslov		The role of microRNAs in heart failure
Tip		članek
Vol. in št.		, št. Vol. 7
Leto izdaje		2020
Obseg		str. 1-10
ISSN		2297-055X
Jezik		eng
Abstrakt		MicroRNAs are highly investigated for their role in the pathogenesis of cardiovascular diseases. Nevertheless, evidence for clinical implementation is still lacking. In our systematic review, we evaluated the potential of microRNAs as pathophysiological and diagnostic biomarkers of heart failure. We identified 72 differentially expressed microRNA molecules among groups of heart failure patients and control groups by searching the PubMed database. We did not identify a substantial overlap of differentially expressed microRNAs among different studies; only five microRNAs (miR-1228, miR-122, miR-423-5p, miR-142-3p, and exosomal miR-92b-5p) were differentially expressed in more than one included study. Gene set enrichment analysis, based on the gene targets of microRNAs presented in the included studies, showed that gene targets of differentially expressed microRNAs were enriched in the MAPK, TGF[beta], PI3K-Akt, and IL-2 signaling pathways, as well as apoptosis pathway, p53 activity regulation, and angiogenesis pathway. Results of our systematic review show that there is currently insufficient support for the use of any of the presented microRNAs as pathophysiological or prognostic biomarkers in the clinical setting.
Proste vsebinske oznake		heart failure biomarker epigenetics srčno popuščanje biomarker epigenetika