Avtor/Urednik		Korenč, Monika; Zieleskiewicz, Laurent; Stopar Pintarič, Tatjana; Blajić, Iva; Ambrožič, Jana; Lučovnik, Miha
Naslov		The effect of vitamin C on pulmonary oedema in patients with severe preeclampsia
Tip		članek
Vol. in št.		, št. Vol.
Leto izdaje		2021
Obseg		str. str.
ISSN		2352-5568
Jezik		eng
Abstrakt		Objective To determine whether vitamin C in the first three days postpartum reduces pulmonary oedema (PE) assessed by lung ultrasound in patients with severe preeclampsia. Design Randomised, placebo-controlled, double-blind trial. Setting Tertiary perinatal centre. Population Consecutively admitted patients with singleton pregnancies complicated by severe preeclampsia. Methods Thirty-four patients received vitamin C (1.5g/6hours) (n=17) or placebo (n=17) at days 1, 2, and 3 postdelivery. Mann-Whitney-U test was used to compare vitamin C vs placebo groups. A p<-0.05 was considered statistically significant. Main Outcome Measures Lung ultrasound was performed once daily in the first three days following delivery. Echo Comet Score (ECS) on day 1 postdelivery was the primary outcome studied and was obtained using the 28-rib interspaces technique. ECS on days 2 and 3 postdelivery were secondary outcomes. Results There was no significant difference in ECS on day 1 (median 23 (inter-quartile range (IQR) 21-61) vs 18 (IQR 8-35); p = 0.31). All ultrasound examinations on day 1 were performed within six hours from delivery. On days 2 and 3, ECS was significantly lower in vitamin C group compared to placebo (8 (IQR 3-14) vs 35 (IQR 15-78); p=0.03 and 5 (IQR 3-10) vs 18 (IQR 18-44); p=0.04, respectively). Conclusion A single dose of intravenous vitamin C did not reduce PE in postpartum patients with severe preeclampsia on day 1 after delivery. Repeated doses, however, seem to have a delayed effect with a reduction in PE detected on ultrasound on days 2 and 3 following delivery.
Proste vsebinske oznake		askorbinska kislina ultrazvok pljuč preeklampsija ascorbic acid lung ultrasound preeclampsia