Avtor/Urednik		Brčić, Luka; Klikovits, Thomas; Megyesfalvi, Zsolt; Mosleh, Berta; Sinn, Katharina; Hritcu, Richard; Laszlo, Viktoria; Čufer, Tanja; Rozman, Aleš; Kern, Izidor; Mohorčič, Katja
Naslov		Prognostic impact of PD-1 and PD-L1 expression in malignant pleural mesothelioma
Tip		članek
Vol. in št.		Letnik 10
Leto izdaje		2021
Obseg		str. 1-14
ISSN		2226-4477
Jezik		eng
Abstrakt		Background: Programmed cell death 1/programmed death ligand 1 (PD-1/PD-L1) immune-checkpoint blockade is a promising new therapeutic strategy in cancer. However, expression patterns and prognostic significance of PD-L1 and PD-1 are still controversial in human malignant pleural mesothelioma (MPM). Methods: Formalin-fixed paraffin-embedded (FFPE) tumor samples from 203 MPM patients receiving standard treatment without immunotherapy were collected from 5 European centers. PD-L1 and PD-1 expression of tumor cells (TCs) and tumor-infiltrating lymphocytes (TILs) were measured by immunohistochemistry and correlated with clinical parameters and long-term outcome. Results: High (>10%) PD-L1 TC and PD-1 TILs expressions were found in 18 (8%) and 39 (24%) patients, respectively. PD-L1 was rarely expressed by TILs [>/=1%, n=13 (8%); >10%, n=1]. No significant associations were found between the PD-L1 or PD-1 expression of TCs or TILs and clinicopathological parameters such as stage or histological subtype. Notably, patients with high (>10%) TC-specific PD-L1 expression exhibited significantly worse median overall survival (OS) (6.3 vs. 15.1 months of those with low TC PD-L1 expression; HR: 2.51, P<0.001). In multivariate cox regression analysis adjusted for clinical parameters, high TC PD-L1 expression (>10%) proved to be an independent negative prognostic factor for OS (HR: 2.486, P=0.005). There was no significant correlation between PD-L1 or PD-1 expression of TILs and OS. Conclusions: In this multicenter cohort study, we demonstrate that high (>10%) PD-L1 expression of TCs independently predicts worse OS in MPM. Further studies are warranted to investigate the value of PD-L1/PD-1 expression as a marker for treatment response in MPM patients receiving immunotherapy.
Deskriptorji		Mesothelioma Prognosis Mezoteliom Prognoza Anatomy and histology Analysis Anatomija in histologija Analiza
Proste vsebinske oznake		maligni plevralni mezoteliom ligand programirane celične smrti 1 programirana celična smrt 1 PD-L1 malignant pleural mesothelioma programmed death-ligand 1 programmed cell death 1 PD-L1