Avtor/Urednik		Meier, Samuel M.; Kreutz, Dominique; Winter, Lilli; Klose, Matthias H. M.; Cseh, Klaudia; Weiss, Tamara; Bileck, Andrea; Alte, Beatrix; Mader, Johanna C.; Wiche, Gerhard
Naslov		An organoruthenium anticancer agent shows unexpected target selectivity for plectin
Tip		članek
Vol. in št.		Letnik 56, št. 28
Leto izdaje		2017
Obseg		str. 8267-8271
ISSN		1433-7851 - Angewandte Chemie (International ed. in English)
Jezik		eng
Abstrakt		Organometallic metal(arene) anticancer agents require ligand exchange for their anticancer activity and this is generally believed to confer low selectivity for potential cellular targets. However, using an integrated proteomics-based target-response profiling approach as a potent hypothesisgenerating procedure, we found an unexpected target selectivity of a ruthenium(arene) pyridinecarbothioamide (plecstatin) for plectin, a scaffold protein and cytolinker, which was validated in a plectin knock-out model in vitro. Plectin targeting shows potential as a strategy to inhibit tumor invasiveness as shown in cultured tumor spheroids while oral administration of plecstatin- 1 to mice reduces tumor growth more efficiently in the invasive B16 melanoma than in the CT26 colon tumor model.
Proste vsebinske oznake		plectin anticancer agents colon plektin sredstva proti raku debelo črevo