Avtor/Urednik		Tratnjek, Larisa; Jeruc, Jera; Romih, Rok; Zupančič, Daša
Naslov		Vitamin A and retinoids in bladder cancer chemoprevention and treatment
Tip		članek
Vol. in št.		Letnik 22, št. 7
Leto izdaje		2021
Obseg		str. 1-19
ISSN		1422-0067 - International journal of molecular sciences
Jezik		eng
Abstrakt		Bladder cancer (BC) is the tenth most common cancer worldwide with a high recurrence rate, morbidity and mortality. Therefore, chemoprevention and improved treatment of BC are of paramount importance. Epidemiological studies suggest that adequate vitamin A intake may be associated with reduced BC risk. In addition, retinoids, natural and synthetic derivatives of vitamin A, are intensively studied in cancer research due to their antioxidant properties and their ability to regulate cell growth, differentiation, and apoptosis. Findings from in vivo and in vitro models of BC show great potential for the use of retinoids in the chemoprevention and treatment of BC. However, translation to the clinical practice is limited. In this narrative review we discuss: (i) vitamin A and retinoid metabolism and retinoic acid signalling, (ii) the pathobiology of BC and the need for chemoprevention, (iii) the epidemiological evidence for the role of dietary vitamin A in BC, (iv) mechanistic insights obtained from in vivo and in vitro models, (v) clinical trials of retinoids and the limitations of retinoid use, (vi) novel systems of retinoid delivery, and (vii) components of retinoid signalling pathways as potential novel therapeutic targets.
Proste vsebinske oznake		bladder cancer vitamin A retinoic acid signalling rak mehurja vitamin A signalizacija retinojske kisline