Avtor/Urednik		Kačar, Mark; Fitton, John; Gough, Andrew K; Buch, Maya H; McGonagle, Dennis; Savic, Sinisa
Naslov		Mixed results with baricitinib in biological-resistant adult-onset Still's disease and undifferentiated systemic autoinflammatory disease
Tip		članek
Vol. in št.		Letnik 6, št. 2
Leto izdaje		2020
Obseg		str. 1-5
ISSN		2056-5933 - RMD open
Jezik		eng
Abstrakt		This clinical case series describes our experience with the use of Janus kinase 1/2 inhibitor baricitinib in two patients suffering from refractory adult-onset Still's disease (AOSD) as well as in one case suffering from AOSD-like autoinflammatory disease in the context of myelodysplastic syndrome. All patients suffered from disease nonresponsive to conventional Disease-modifying antirheumatic drugs (DMARDs) as well as biological therapies including interleukin (IL)-1 and IL-6 blockade, relying instead on high daily doses of prednisolone. We also report the first case of Pneumocystis jirovecii infection following baricitinib use.
Deskriptorji		Still's disease, adult onset Spondylitis, ankylosing Arthritis Antirheumatic agents Stillova bolezen s pričetkom v odrasli dobi Ankilozirajoči spondilitis Artritis Antirevmatična sredstva Drug therapy Zdravljenje z zdravili
Proste vsebinske oznake		undifferentiated systemic autoinflammatory disease disease-modifying antirheumatic drugs nediferencirana sistemska avtovnetna bolezen imunomodulirajoči antirevmatiki