Avtor/Urednik		Podlipnik, Žiga; Umek, Nejc; Kavšek, Gorazd; Blajić, Iva; Stopar Pintarič, Tatjana
Naslov		The use of prothrombin-complex with fibrinogen concentrate for ROTEM-guided management of severe coagulopathy associated with minor placental abruption
Tip		članek
Vol. in št.		Letnik 70, št. br. 4
Leto izdaje		2020
Obseg		str. 371-374
ISSN		1330-0164 - Acta medica Croatica : časopis Hrvatske akademije medicinskih znanosti
Jezik		eng
Abstrakt		Placental abruption can cause signifi cant hemorrhage and coagulopathy that can progress rapidly due to consumption and depletion of clotting factors. Rapid detection and treatment of hypofi brinogenemia is essential in the evolving clinical and hematologicmilieu. The use of ROTEM allows a dynamic monitoring of coagulopathy. So far, only fi brinogen concentrate has been described for prompt management of severe coagulopathy associated with placental abruption. We report a case of a 40-year-old multipara with minor placental abruption complicated by severe coagulopathy, where a combination of prothrombincomplex and fi brinogen concentrate was used for prompt treatment. Potential benefi ts and drawbacks of prothrombin complex concentrate therapy, as well as diagnostic and therapeutic considerations of ROTEM - guided test are discussed.
Proste vsebinske oznake		coagulopathy placental abruption prothrombin complex concentrate koagulopatija abrupcija posteljice koncentrat protrombinskega kompleksa