Avtor/Urednik		Primorac, Dragan; Stojanović Stipić, Sanda; Strbad, Marko; Girandon, Lenart; Barlič, Ariana; Frankić, Mileva; Ivić, Ivo; Marasović Krstulović, Daniela; Jukić, Irena; Halassy, Beata; Hećimović, Ana; Matišić, Vid; Molnar, Vilim
Naslov		Compassionate mesenchymal stem cell treatment in a severe COVID-19 patient
Tip		članek
Vol. in št.		Letnik 62, št. 3
Leto izdaje		2021
Obseg		str. 201-209
ISSN		0353-9504 - Croatian medical journal
Jezik		eng
Abstrakt		COVID-19 presentations range from cold-like symptoms to severe symptoms with the development of acute re-spiratory distress syndrome (ARDS). We report on a severe COVID-19 patient who was mechanically ventilated and who developed ARDS and bacterial infection. Because of rapid clinical deterioration and the exhaustion of other treatment options, the family and attending physicians requested a compassionate use of adult allogeneic bone marrow-derived mesenchymal stem cells (MSC) in addi-tion to commonly used immunosuppressive, antiviral, and supportive therapy. The clinical course is discussed thor-oughly, with a special emphasis on the safety and effect of MSC therapy. Compassionate MSC treatment, given in three rounds, affected ARDS regression. The patient was discharged from the intensive care unit after 31 days and from hospital after 49 days in a good general condition. MSC treatment was not associated with any side effects and was well tolerated in a three-week period; therefore, it should be studied in larger trials and considered for com-passionate use.
Proste vsebinske oznake		COVID-19 symptoms acute respiratory distress syndrome COVID-19 acute re-spiratory distress syndrome genomske variante