Avtor/Urednik		Žakelj-Mavrič, M
Naslov		The role of hydroxysteroid dehydrogenases in man and in microorganisms
Tip		članek
Vir		Acta Chim Slov
Vol. in št.		Letnik 42, št. 3
Leto izdaje		1995
Obseg		str. 363-71
Jezik		eng
Abstrakt		Hydroxysteroid dehydrogenases (HSD) are involved in the biosynthesis of steroid hormones in classical steroidogenic tissues. In addition, HSD are important in peripheral target tissues, where they regulate intracellular concentrations of active steroid signalling molecules. HSD can be found in microorganisms, in bacteria, and fungi. Although their role in microbial cells is not yet quite clear, our results indicate that 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) from the fungus Cochliobolus lunatus might be involved in the regulation of intracellular testosterone concentrations. The study of microbial and especially fungal HSD is promising as the results might help to elucidate the evolution of HSD and steroid hormone signalling system.
Deskriptorji		HYDROXYSTEROID DEHYDROGENASES STEROIDS FUNGI BACTERIA