Avtor/Urednik		Sinreih, Maša; Jójárt, Rebeka; Kele, Zoltán; Büdefeld, Tomaž; Paragi, Gábor; Mernyák, Erzsébet; Lanišnik-Rižner, Tea
Naslov		Synthesis and evaluation of AKR1C inhibitory properties of A-ring halogenated oestrone derivatives
Tip		članek
Leto izdaje		2021
Obseg		str. str.
ISSN		1475-6366 - Journal of enzyme inhibition and medicinal chemistry
Jezik		eng
Abstrakt		Facile syntheses of 3-O-carbamoyl, -sulfamoyl, or -pivaloyl derivatives of 13[alpha]-oestrone and its 17-deoxy counterpart have been carried out. Microwave-induced, Ni-catalysed Suzuki-Miyaura couplings of the newly synthesised phenol esters with phenylboronic acid afforded 3-deoxy-3-phenyl-13a-oestrone derivatives. The carbamate and pivalate esters proved to be suitable for regioselective arylations. 2-(4- Substituted) phenyl derivatives were synthesised via Pd-catalysed, microwave-assisted C-H activation reactions. An efficient, one-pot, tandem methodology was elaborated for the introduction of the carbamoyl or pivaloyl group followed by regioselective C-2-arylation and subsequent removal of the directing group. The antiproliferative properties of the novel 13a-oestrone derivatives were evaluated in vitro on five human adherent cancer cell lines of gynaecological origin. 3-Sulfamate derivatives displayed substantial cell growth inhibitory potential against certain cell lines. The newly identified antiproliferative compounds having hormonally inactive core might be promising candidates for the design of more active anticancer agents.
Proste vsebinske oznake		aldo-keto reduktaze halogenirani derivati estrona zaviranje aldo-keto reductases halogenated oestrone derivates inhibition