Avtor/Urednik | Tóthová, Zuzana; Šemeláková, Martina; Solárová, Zuzana; Tomc, Jana; Debeljak, Nataša; Solár, Peter | |
Naslov | The role of PI3K/AKT and MAPK signaling pathways inerythropoietin signalization | |
Tip | članek | |
Vol. in št. | Letnik 22, št. 14 | |
Leto izdaje | 2021 | |
Obseg | str. 1-14 | |
ISSN | 1422-0067 - International journal of molecular sciences | |
Jezik | eng | |
Abstrakt | Erythropoietin (EPO) is a glycoprotein cytokine known for its pleiotropic effects on varioustypes of cells and tissues. EPO and its receptor EPOR trigger signaling cascades JAK2/STAT5,MAPK, and PI3K/AKT that are interconnected and irreplaceable for cell survival. In this article, wedescribe the role of the MAPK and PI3K/AKT signaling pathways during red blood cell formationas well as in non-hematopoietic tissues and tumor cells. Although the central framework of thesepathways is similar for most of cell types, there are some stage-specific, tissue, and cell-lineagedifferences. We summarize the current state of research in this field, highlight the novel members ofEPO-induced PI3K and MAPK signaling, and in this respect also the differences between erythroidand non-erythroid cells. | |
Proste vsebinske oznake | eritropoetin PI3K MAPK erythropoietin PI3K MAPK |