Avtor/Urednik		Berbers, Guy; Van Gageldonk, Pieter; Van de Kassteele, Jan; Wiedermann, Ursula; Desombere, Isabelle; Dalby, Tine; Toubiana, Julie; Tsiodras, Sotirios; Paluska Ferencz, Ildikó; Kastrin, Tamara
Naslov		Circulation of pertussis and poor protection against diphtheria among middle-aged adults in 18 European countries
Tip		članek
Vol. in št.		Letnik iss. 1, št. Vol. 12
Leto izdaje		2021
Obseg		str. 1-13 str.
ISSN		2041-1723 - Nature communications
Jezik		eng
Abstrakt		Reported incidence of pertussis in the European Union (EU) and the European Economic Area (EEA) varies and may not reflect the real situation, while vaccine-induced protection against diphtheria and tetanus seems sufficient. We aimed to determine the seroprevalence of DTP antibodies in EU/EEA countries within the age groups of 40-49 and 50-59 years. Eighteen countries collected around 500 samples between 2015 and 2018 (N = 10,302) which were analysed for IgG-DTP specific antibodies. The proportion of sera with pertussis toxin antibody levels >-100 IU/mL, indicative of recent exposure to pertussis was comparable for 13/18 countries, ranging between 2.7-5.8%. For diphtheria the proportion of sera lacking the protective level (<0.1 IU/mL) varied between 22.8-82.0%. For tetanus the protection was sufficient. Here, we report that the seroprevalence of pertussis in these age groups indicates circulation of B. pertussis across EU/EEA while the lack of vaccine-induced seroprotection against diphtheria is of concern and deserves further attention.
Proste vsebinske oznake		seroprevalence of pertussis proportion antibody levels European Union seroprevalenca oslovskega kašlja delež ravni protiteles Evropska unija