Avtor/Urednik		Ropret, Sandra; Jeriha, Jakob; Sorčan, Tjaša; Rogar, Marija; Zemljič Jokhadar, Špela; McGrath, John A.; Ilic, Dusko; Liović, Mirjana
Naslov		Induced pluripotent stem cell (iPSC) line MLi-004A derived from a patient with recessive dystrophic epidermolysis bullosa (RDEB)
Tip		članek
Vol. in št.		, št. Vol. 55
Leto izdaje		2021
Obseg		str. 1-5
ISSN		1876-7753 - Stem cell research
Jezik		eng
Abstrakt		We have generated MLi004-A, a new induced pluripotent stem cell (iPSC) line derived from skin fibroblasts of a female patient with recessive dystrophic epidermolysis bullosa (RDEB). This iPSC line may be used as a model system for studies on skin integrity, the extracellular matrix and skin barrier function. The characterization of the MLi004-A cell line consisted of molecular karyotyping, next-generation sequencing of the COL7A1 alleles, plu-ripotency and differentiation potentials testing by immunofluorescence of associated markers in vitro. The MLi- 004A line has been also tested for ability to differentiate into fibroblasts.
Proste vsebinske oznake		matične celice epidermoliza kolagen VII stem cell epidermolysis collagen VII