Avtor/Urednik		Vervaet, Benjamin A.; Nast, Cynthia C.; Schreurs, Gerd; Jayasumana, Channa; Herath, Chula; Kojc, Nika; De Broe, Marc E.
Naslov		Chronic interstitial nephritis in agricultural communities
Tip		članek
Vol. in št.		Letnik 17, št. suppl.
Leto izdaje		2021
Obseg		str. 45-50
ISSN		1769-7255 - Néphrologie & thérapeutique
Jezik		eng
Abstrakt		Chronic interstitial nephritis in agricultural communities is a devastating kidney disease with a globally increasing prevalence. Its cause is unknown. Two predominant etiologies are hypothesised: recurrent episodes of dehydration and exposure to environmental toxins, such as agrochemicals and metals. In this review, we summarise arguments on: 1) why heat stress/dehydration is an unlikely cause of this disease and 2) why chronic interstitial nephritis in agricultural communities is to be considered a toxin-induced nephropathy. Mechanistically, we provide arguments for a putative role of pesticides on the one hand, and the calcineurin pathway on the other hand, both of which require further investigation. Finally, we summarise several important perspectives for research on chronic interstitial nephritis in agricultural communities.
Proste vsebinske oznake		kronična ledvična bolezen zaviranje kalcinevrina nefrotoksičnost chronic kidney disease calcineurin inhibition nephrotoxicity