Avtor/Urednik		Žgajnar, J
Naslov		Prognostična vrednost katepsina D in PS2 pri operabilnem raku dojk
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		1995
Obseg		str. 49
Jezik		slo
Abstrakt		Our assessment of prognosis in operable breast cancer patients and the choice of an appropriate therapy is based on prognostic factors. Promising prognostic factors include cathepsin D, a lysosomal protease and PS2, a protein of yet unknown function. We studied the prognostic value of cathepsin D and PS2 for disease-free and overall survival in 153 operable breast cancer patients treated at the Institute of Oncology in Ljubljana. Levels of cathepsin D and PS2 were immunoradiometrically determined in frozen tumour cytosols. The median folow-up period was 33 months. Univariate statistical analysis (Log Rank test) was performed to evaluate the survival. Out of 153 patients included in the study 43 patients (28 percent) relapsed and 24 patients (16 percent) died. The overall survival of patients with cathepsin D levels less th-50 pmol/mg prot. values. The difference in disease-free survival was not statistically significant (p=0,09). The overall survival of patients with PS2 levels more th.2,2/mg prot was significantly better than that of the patients with PS2 levels less th.-2,2 ng/mg prot. (p=0,02). The difference in disease-free survival was not statistically significant (p=0,48). The overall survival of patients with PS2 levels more th2,2ng/mg prot in the axillary lymph node positive subgroup was significantly better than that of the patients with PS2 levels less th-2,2 (p=0,02). Our univariate analysis has confirmed the prognostic value of cathepsin D and PS2 for overall survival but not for disease-free survival. Furthermore we have found that PS2 is particularly useful i n the axillary lymph node positive subgroup for the evaluation of overall survival.
Deskriptorji		BREAST NEOPLASMS TREATMENT OUTCOME CATHEPSIN D TUMOR MARKERS, BIOLOGICAL SURVIVAL RATE CYTOSOL IMMUNORADIOMETRIC ASSAY LYMPH NODES LYMPHATIC METASTASIS