Avtor/Urednik		Gjorgoska, Marija; Lanišnik-Rižner, Tea
Naslov		Estrogens and the Schrödinger's cat in the ovarian tumor microenvironment
Tip		članek
Vol. in št.		Letnik 13, št. 19
Leto izdaje		2021
Obseg		str. 1-18
ISSN		2072-6694 - Cancers
Jezik		eng
Abstrakt		Ovarian cancer is a heterogeneous disease affecting the aging ovary, in concert with a complex network of cells and signals, together representing the ovarian tumor microenvironment. As in the "Schrödinger's cat" thought experiment, the context-dependent constituents of the-by the time of diagnosis-well-established tumor microenvironment may display a tumor-protective and -destructive role. Systemic and locally synthesized estrogens contribute to the formation of a pro-tumoral microenvironment that enables the sustained tumor growth, invasion and metastasis. Here we focus on the estrogen biosynthetic and metabolic pathways in ovarian cancer and elaborate their actions on phenotypically plastic, estrogen-responsive, aging immune cells of the tumor microenvironment, altogether highlighting the multicomponent-connectedness and complexity of cancer, and contributing to a broader understanding of the ovarian cancer biology.
Proste vsebinske oznake		rak jajčnikov estrogeni imunosupresivno mikrookolje ovarian cancer estrogens immunosuppressive microenvironment