Avtor/Urednik		Fakhr, Elham; Modic, Živa; Cid-Arregui, Angel
Naslov		Recent developments in immunotherapy of cancers caused by human papillomaviruses
Tip		članek
Vol. in št.		, št. Vol. 163
Leto izdaje		2020
Obseg		str. 33-45
ISSN		1365-2567 - Immunology
Jezik		eng
Abstrakt		A subset of oncogenic human papillomaviruses (HPVs) is the main cause of genital cancers, most importantly cervical cancer and an increasing number of head and neck cancers. Despite the availability of prophylactic vaccines against the most prevalent oncogenic HPV types, HPV-induced malignancies are still a major health and economic burden. Besides conventional treatment with surgery, chemotherapy and radiation, immunotherapy is emerging as an efficient adjuvant option. Here, we review relevant studies and ongoing clinical trials using immune checkpoint inhibitors, therapeutic vaccines, gene editing approaches and adoptive T cell therapies, with special focus on engineered TCR T cells, which are showing encouraging results and could lead to significant improvement in the treatment of HPV+-infected cancer patients.
Proste vsebinske oznake		HPV rak materničnega vratu humani papiloma virus imunoterapija cervical cancer human papillomavirus immunotherapy